surveillance for hepatocellular carcinoma after autologous stem cell transplantation in cirrhosis

نویسندگان

mehdi mohamadnejad

mandana ashrafi

kamran alimoghaddam

masoud vosough

چکیده

background: during the resent years there has been interest in using bone marrow stem cells to treat liver cirrhosis. however, there is a potential concern for malignant transformation after stem cell therapy. the aim of this study was to evaluate the development of hepatocellular carcinoma (hcc) after autologous bone marrow stem cell transplantation for liver cirrhosis. methods: all the patients who underwent autologous stem cell transplantation for liver cirrhosis between 2005 and 2011 at our center were enrolled. cellular infusion was made through peripheral vein, portal vein, or hepatic artery. the patients were invited to undergo screening for hepatocellular carcinoma. the screening was made with ultrasonography and alpha-feto protein (afp) measurement. results: thirty two patients (18 males) were included in the study. mean age of patients was 45.7 years. fifteen patients (47%) received mesenchymal stem cell (msc), 9 (28%) received bone marrow mononuclear cells, 5 (16%) were given cd 133-positive bone marrow cells, and 3 (9%) patients received cd 34-positive bone marrow cells. mean duration of follow up was 20.5 months. mean serum level of afp was 2.8 ng/ml at baseline and 3.4 ng/ml at the end of follow up (p= 0.3). one patient was found to have hepatocellular carcinoma three months after infusion of bone marrow mononuclear cells. the incidence rate for hcc was 1.8 cases per 100 person-years in this study. conclusion: autologous bone marrow stem cell infusion does not appear to increase the risk of hepatocellular carcinoma. the incidence rate of hcc in this study is comparable or even less than the reported rates of hcc in cohort studies of cirrhotic patients.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Surveillance for Hepatocellular Carcinoma after Autologous Stem Cell Transplantation in Cirrhosis

BACKGROUND During the resent years there has been interest in using bone marrow stem cells to treat liver cirrhosis. However, there is a potential concern for malignant transformation after stem cell therapy. The aim of this study was to evaluate the development of hepatocellular carcinoma (HCC) after autologous bone marrow stem cell transplantation for liver cirrhosis. METHODS All the patien...

متن کامل

Osteoporosis after stem cell transplantation

Background Stem cell transplantation has become as a novel treatment  for end-stage kidney, lung, heart , liver diseases and several hematologic disorders. Improved survival of transplant recipients has raised awareness of post-transplant complications. One of these complications is transplant-related osteoporosis. Methods  In this manuscript we review prevention methods for transplant-relat...

متن کامل

Surveillance of cirrhosis for hepatocellular carcinoma

1 Peninsula Technology Assessment Group (PenTAG), Peninsula Medical School, Exeter, UK 2 School of Mathematics and Statistics, University of Plymouth, UK 3 Hepatology Research Group, Peninsula Medical School, Exeter, UK 4 Radiology Department, Plymouth NHS Hospitals Trust, UK 5 Queen’s Medical Centre, University of Nottingham, UK 6 Southampton Health Technology Assessments Group, University of ...

متن کامل

Hodgkin’s Lymphoma Occurring Secondary to Autologous Stem Cell Transplantation in Plasma Cell Leukemia; A Case Report

Survival of patients with multiple myeloma has improved substantially because of availability of new therapies including autotransplants, immunomodulating drugs and proteasome-inhibitors. Second primary cancers have emerged as an important determinant of morbidity and mortality among cancer survivors. Even though there is an increased risk of new cancers of the lymphoreticular and haematopoetic...

متن کامل

Oral Ciprofloxacin Prophylaxis in Patients Undergoing High Dose Therapy and Autologous Hematopoietic Stem Cell Transplantation

Background: Antibiotic prophylaxis is usually used in allogenic stem cell transplantation, but its use in Autologous Stem Cell Transplantation (ASCT) is controversial. We evaluated the efficacy of ciprofloxacin prophylaxis in ASCT. Materials and Methods: To identify the efficacy of ciprofloxacin on the incidence of neutropenic fever and its complications, 72 patients had been admitted to Talegh...

متن کامل

Autologous Stem Cell Transplantation for Aggressive Lymphomas

The role of high-dose therapy (HDT) followed by autologous stem cell transplantation (ASCT) in the treatment armamentarium of aggressive B- and T-cell non-Hodgkin lymphoma (NHL) is still a matter of debate. In the pre-Rituximab era, the PARMA study demonstrated the superiority of HDT/ASCT over conventional salvage chemotherapy in chemosensitive, relapsed patients. Subsequently, HDT/ASCT has bec...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
middle east journal of digestive diseases

جلد ۴، شماره ۳، صفحات ۱۴۵-۰

کلمات کلیدی

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023